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First-line treatment typically includes dietary advice, topical preparations (e.g., soothing ointments), and addressing underlying constipation

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The mechanisms are not fully understood but may involve delayed gastric emptying, activation of the area postrema in the central nervous system, changes in nutrient absorption, and altered intestinal motility [116,117,118]

Gq/11 is believed to interact with PLC, which may then cleave a lipid molecule called phosphatidylinositol 4,5-bisphosphate (PIP2) into two secondary messengers: IP3 (Inositol trisphosphate) and DAG (Diacylglycerol)

[DOI] [PubMed] [Google Scholar] 45.Tong G., Peng T., Chen Y., Sha L., Dai H., Xiang Y., Zou Z., He H., Wang S