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Recent epidemiological studies have aimed to study the relationship between PD occurrence/progression and T2D patients receiving metformin therapy

As inflammation is attenuated, insulin signaling in peripheral tissues improves, and weight loss is facilitated, given that chronic inflammation can promote leptin resistance and dysregulated appetite control

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However, these strategies often fail to offer sustainable solutions, as the body's powerful biological mechanisms fight to regain lost weight

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GLP-1 medications like semaglutide and tirzepatide have changed the way many people lose weight