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An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss

5.5 Severe Gastrointestinal Adverse Reactions DOCVARIABLE vault_nd_fcd34bb4-3cb3-473c-864a-ed4ae529f642 \* MERGEFORMAT Use of GLP-1 receptor agonists, including BYDUREON BCISE, has been associated with gastrointestinal adverse reactions, sometimes severe [see Adverse Reactions (6)]

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In fact, above a BMI of 25, that risk was about 30% higher for every 5-unit increase of BMI [13]

The net result, in the liver, is transcriptional repression of the CYP7A1 gene, which encodes the rate-limiting enzyme in the classic pathway of bile acid synthesis

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