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The findings build on clinical trial results announced in December 2025, which found that retatrutide helped people with obesity lose nearly a third of their body weight (around 70 pounds [lb])

Absolute contraindications include hypersensitivity to any component, severe hepatic failure, and sulfur-amino-acid disorders such as homocystinuria

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Description CJC-1295 with DAC 5mg CJC-1295 with DAC is a synthetic long-acting peptide analog of growth hormone-releasing hormone (GHRH), structurally modified with a Drug Affinity Complex (DAC) a maleimidopropionic acid (MPA) group that enables covalent binding to serum albumin, substantially extending the peptides half-life compared to native GHRH sequences

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