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Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment

C., Botros, F

GLP-1 crosses the blood-brain barrier in limited amounts, but the brain also produces its own GLP-1 through neurons in the nucleus tractus solitarius (NTS) of the brainstem

Additional precautions may include extended fasting periods beyond standard protocols, preoperative ultrasound to assess gastric contents, and consideration of rapid sequence induction for general anesthesia

doi: 10.1016/j.tem.2016.03.017 81 SlleyEKunSSzijrtIAKertszMWittmannIMolnrGA

Efficacy and safety of oral small molecule glucagon-like peptide 1 receptor agonist danuglipron for glycemic control among patients with type 2 diabetes: a randomized clinical trial