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In the STEP 1 extension study, participants who stopped semaglutide after treatment regained a substantial portion of the weight they had lost during the following year, and cardiometabolic improvements moved back toward baseline

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While studies in the human intestine have revealed important fibroblast heterogeneity and localization 1,2,3,5,7 , the full complement of fibroblast subtypes and their spatial complexity had not been mapped in the developing or adult small intestine