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About monitoring: How will we know this treatment is working, and what changes would trigger a switch

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Though the gene encoding DSIP has not been identified and its receptor remains unknown, emerging studies indicate that its activity may be mediated through NMDA receptors in the brain and 1-adrenergic pathways in peripheral tissues

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Darisipudi MN, Kulkarni OP, Sayyed SG, Ryu M, Migliorini A, Sagrinati C, Parente E, Vater A, Eulberg D, Klussmann S, Romagnani P, Anders HJ