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The Mechanisms of Semaglutide Therapy in Heart Failure Patients trial will assess the impact of semaglutide on biomarkers, echocardiographic parameters, and functional outcomes in patients with HF [63]

Multiple banks, such as BMO Capital Markets, 8 Morningstar 9 and Goldman Sachs 10 expect the market to grow to or beyond $100bn by 2030, with some, such as JP Morgan, 11 predicting as high as $140bn by 2032

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Current clinical data has not highlighted a significant, consistent difference in the onset timeline between sexes

Not yet available on the NHS: UK access awaits successful phase 3 results, regulatory approval and a positive NICE appraisal

Pancreatic alpha cell-derived glucagon-related peptides are required for beta cell adaptation and glucose homeostasis