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and it does not typically cause insomnia, anxiety, or the cardiovascular effects (marked hypertension, tachycardia) characteristic of stimulants

Although GLP-1RAs can reduce inflammatory signaling, this effect does not necessarily ensure that precursor inflow remains proportionate to ongoing NAD turnover [75, 105]

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Once the uterine contractions begin, they may stimulate further release of Oxytocin, leading to higher frequency and intensity of the contractions via a positive feedback mechanism

The clinical phenotype is variable and has been classified into neonatal onset forms, with the most severely affected patients presenting with congenital anomalies (Type I) or without anomalies (Type II), and mild and/or later onset (Type III) [138]