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This is especially true early in treatment, during dose increases, or on days when you feel full quickly

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Clinical studies on this ingredient showed no irritation, sensitization, or phototoxicity

Common Clinical Use The most commonly used PDE-4 inhibitor is roflumilast, indicated for: Severe COPD associated with chronic bronchitis Patients with frequent COPD exacerbations It is usually used as add-on therapy to bronchodilators

Provides better temperature stability and tolerance due to the allowance of higher discharge rate

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