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Activated B cells can migrate to bone tissue and directly promote osteoclast formation by releasing osteoclastogenic factors: RANKL, TNF, and IL-1, thereby accelerating bone resorption (234)

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doi: 10.1080/10408398.2010.517876 223 ReddyM

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If these projections hold, orforglipron could become the first GLP-1 therapy that is realistically accessible to the tens of millions of Americans who qualify for treatment but cannot currently get it