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(3) Stage-adaptive targeting addresses evolving plaque biology [142], with PBNs unique hemodynamic stability enabling: (i) endothelial activation/neutrophil recruitment during early atherogenesis, (ii) foam cell/collagen fiber targeting in progressive plaques, and (iii) thrombus/necrotic core engagement in unstable lesions [99]

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Current single-nucleus RNA-seq datasets from human AD tissue reveal distinct ferroptosis-related transcriptional programs in glial cells, including upregulation of TFRC, FTH1, SLC40A1, and ACSL4, which indicate enhanced iron turnover and lipid peroxidation susceptibility (Leng et al., 2021)

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Doses above 100mg methionine per administration produced no further increase in VLDL export rates measured via stable isotope tracer studies