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402 CBP/p300 Using the ovarian cancer cell line SKOV3, it has been reported that Staphylococcal nuclease domain-containing protein 1 (SND1) regulates the gene transcriptional activation of SLUG (an epithelial-to-mesenchymal transition marker) by increasing chromatin accessibility through the recruitment of the acetyltransferases GCN5 and CBP/p300 to the SLUG promoter proximal region

Keatley questions the claim that insulin resistance is the universal cause of a slowed metabolism

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These observations prompted new clinical studies designed specifically to measure GLP-1's effect on weight loss rather than glucose control

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Annals of the New York Academy of Sciences 2008