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in the latter, proopiomelanocortin (POMC) neurons are present and it is believed that endogenous GLP-1 induces satiety, affecting both anorexigenic and orexigenic signaling pathways
However, the underlying mechanism for GLP-1 accomplishing this is not known, as whether or not GLP-1R is localised to the islet alpha-cell surface is a matter of debate
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Duration planning for semaglutide should start at the beginning of treatment, not at the end
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