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Topical NSAIDs (such as ibuprofen gel) offer localised pain relief with minimal systemic absorption and are recommended by NICE as first-line for localised joint pain

Treatment of Vitamin B12 Deficiency Treatment of vitamin B12 deficiency in the UK follows established guidelines, with the approach depending on the cause, severity, and presence of neurological symptoms

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In addition to decreasing homocysteine levels, which could potentially help reduce the risk of heart disease, some research also indicates that higher vitamin B12 levels may be linked to improved outcomes for those who have suffered from an ischemic stroke and may be associated with a lower risk of coronary artery disease