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Subsequent work by Heffernan and coworkers (2001) confirmed the peptides effects in obese mouse models, with chronic administration associated with reduced body weight gain and decreased adiposity without concurrent changes in food intake

IGF-1 LR3 is investigated in preclinical research for IGF-1R signaling, PI3K/Akt/mTOR pathway activation, skeletal muscle protein synthesis, and metabolic pathway research

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