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Additionally, diabetes disrupts the tight junctions between Sertoli cells that constitute the BTB, compromising its integrity and permitting harmful systemic factors to infiltrate the seminiferous epithelium

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Fatty acid oxidation and control of food intake

ROS generation increases BBB permeability, which is a characteristic of TBI

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Clinician groups further highlighted that lifestyle modifications alone are often insufficient to achieve the weight loss needed to improve obesity-related complications like T2DM and MASLD