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Interestingly, injecting mice with 400 ng of recombinant mouse IL-6 twice daily for 7 days significantly increases fasting plasma active GLP-1, as well as ileal Gcg and Pcsk1 mRNA, but not plasma GLP-2 (ELISA) or DPP4 activity (Ellingsgaard et al., 2011)

Current Phase 2 trial data associate retatrutide with dose-dependent increases in resting heart rate, but no increase in major adverse cardiovascular events was observed

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Professor Loo noted: Because there are no subjective effects from the saline, in previous studies it became obvious which people were receiving the ketamine and which people received placebo

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