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Longterm activation of MC1R, either physiologically or pharmacologically, has not been shown to be associated with increased incidence of melanoma whereas lossoffunction variants in MC1R have been associated with an increased risk of melanoma

Hildebrandt MA , Ye Y, Zhou Y, Orlowski R, Wu X

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Unlike standard cytoprotective agents that exhibit only prophylactic effectiveness (shared limitation of activity)[9,10,12,13,15,16,20], BPC 157 represents a prototype of a more effective class of cytoprotective agents with both prophylactic and therapeutic ability[7,16]

10.1016/j.tifs.2022.10.019 97 SuH.WangD.ZhangT.ZhangX.MaoS.LiC

By definition, the IV method translates to 100% bioavailability, making it superior to oral supplements where much of the nutrient is lost during digestion