Combination therapy with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors in older patients with type 2 diabetes: a real-world evidence study
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Notably, up to 82% of participants achieved an A1C level below 6.5%, and up to 31% reached an A1C level below 5.7%, indicating a potential for normalization of blood glucose levels in some patients [R]
It has been speculated that stopping the GLP-1RA treatment can result in the loss of balance in appetite regulation, though the specific underlying mechanisms remain unclear [105]
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CCK-A receptor antagonists increase calorie intake and reduce satiety, suggesting a possible role of endogenous CCK in appetite regulation.21 CCK may be a very short-term modulator of appetite
