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To determine the site of action in the brain that GLP-1 and Gcg coagonism may be occurring, one group examined c-fos induction upon co-injection of GLP-1 and Gcg (Parker et al., 2013)

In order to compare stabilization of these ligands by the receptor extracellular domain HDX was performed on the peptide ligands in the presence of nGLP-1R (Figure 2)

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Promotes recovery and reduces fatigue

doi: 10.1038/s41577-019-0123-x

If your dose has not been increased in that timeframe, work with your provider to escalate your dose before switching medications