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This critical balance between survival and cell death is orchestrated by the coordinated activity of the three canonical UPR branches, IRE1, PERK, and ATF6, which together determine cell fate decisions under stress

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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Glutathione system in young spontaneously hypertensive rats

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In this scheme, these neurons could produce their own GABA on-demand when needed, while also reducing the need for excessive Put-GABA synthesis that would exacerbate already-high oxidative stress in these neurons (Ju et al., 2022