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However, disruption of this equilibrium, for example through the blockage of mitochondrial fusion and fission, may lead to oxidative stress, mitochondrial dysfunction and metabolic alterations, and ultimately to the development of mitochondria-associated diseases (Xiao et al., 2021)

In the hypoxia state, XBP1u is activated into XBP1 spliced (XBP1s) by IRE1, enabling effective transcription of multiple target genes in the nucleus

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This hormone helps control blood sugar, appetite, and metabolism

It also significantly ameliorated inflammatory factors and inflammatory responses on the hindpaw skin