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Description

188 These findings suggest that CTSB inhibitors may act on both acinar cells and macrophage-driven inflammation and that dual-targeted strategies focusing on CTSB and its downstream signaling (e.g., NF-B) may offer a more comprehensive approach to treatment

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In addition to classical risk factors of atherosclerosis, known since the time of the Framingham Heart Study (FHS), i.e., dyslipidaemia, tobacco smoking, and arterial hypertension, these include obesity, prediabetes and diabetes mellitus, chronic kidney disease, persistent inflammation, sedentary lifestyle, and many others

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Patients should not overlap an investigational retatrutide product with tirzepatide unless they are participating in an authorized clinical study with appropriate oversight

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