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This work is supported by an American Heart Association Predoctoral Fellowship Grant 18PRE33990057 (M.S.), American Heart Association Scientist Development Grant 16SDG29920017 (A.M.L.), an American Cancer Society Institutional Research Grant (IRG-14-190-56) to the Purdue University Center for Cancer Research (A.M.L.), and NIH 1R01HL141076-01 (A.M.L.)