But GHRP-2 elevates cortisol, prolactin, and appetite (food intake increased ~36% in one study)
Park, J
48.0 48.1 Ekins B, Ford D, Thompson M, Bridges R, Rollins D, Jenkins R (1987)
Based on worldwide value sales of the Centrum range
This study also highlights how GHK-Cu influences gene expression related to regeneration and healing, making it broadly active in skin, connective tissue, and organ repair
The most studied mechanisms include: upregulation of growth hormone receptors in fibroblasts (increasing sensitivity to healing signals), activation of the FAK-paxillin pathway (promoting cell adhesion and migration), modulation of the nitric oxide system through Src-Caveolin-1-eNOS phosphorylation (enhancing vascular function), and dual activation of the Egr-1/NAB2 gene loop (promoting organized, non-chaotic blood vessel growth)