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LY2189265, a long-acting glucagon-like peptide-1 analogue, showed a dose-dependent effect on insulin secretion in healthy subjects
PSS upregulated SHP-2 expression in A 1-42 -treated BV-2 cells to activate mitophagy, which subsequently downregulated NLRP3, Apoptosis-associated speck-like protein (ASC), IL-1, IL-18, and Gasdermin D (GSDMD) expression, and inhibited NLRP3 inflammasome activation
Drucker, Mt
Reuters reported that the same trial cut moderate-to-severe obstructive sleep apnea severity by 60.6 percent and reduced knee osteoarthritis pain by up to 73.1 percent, broadening the conditions the drug could address
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