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Mechanistically, NLRP3 activation exacerbated pancreatic injury through caspase-1-dependent maturation of interleukin-1 (IL-1) and gasdermin D (GSDMD)-mediated pyroptosis, perpetuating systemic inflammation

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The survey MS scans ranging from m/z 100 to 1,700 were succeeded by 10 Parallel Accumulation-Serial Fragmentation (PASEF) tandem MS scans with a cycle time of 1.16 s