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Dosage of amitriptyline/nortriptyline should be adjusted, if necessary

Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity

Finally, cells were stained with DAPI for 5 min at RT (100 pg/mL, Thermo Fisher Scientific)

However, excessive intake may lead to side effects such as gastrointestinal discomfort and potential cardiovascular risks

Niacinamide (vitamin B3) may provide additional metabolic support, though the evidence base for this specific combination is still developing

A positive logRR indicated that the antioxidant group had a higher rate of side effects, while a negative value indicated higher rates in the placebo group