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For instance, Alofisel, an allogeneic adipose-derived MSC therapy for Crohns disease [179,180,181], was withdrawn from the European market in December 2024 after the latest clinical trial results showed no significant difference between it and a placebo [182]

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Unlike traditional symptomatic treatments, the primary objective of DMT is to decelerate disease progression by intervening in the pathological mechanisms underlying PD (Elkouzi et al., 2019