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We are grateful to Dr Slava Ziegler for discussions of biological experiments

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The reaction product was extracted with ethyl acetate, and distilled under reduced pressure to obtain 35.87 g (yield: 80 %) of 4-chloro-3-hydroxybutyronitrile

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Finally, the integration of pharmacogenomics into treatment guidelines is not yet feasible due to insufficient clinical validation, although early data are promising