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Without enough fluids, nausea, fatigue, constipation, and headaches may be more likely to arise or become worse

Accessed August 2024 at Elsevier Clinical Pharmacology

Certain situations may require individualized evaluation, but treatment outside approved indications is determined by healthcare providers based on medical judgment and patient-specific circumstances

Prefer topical application over pills or injections

NCCIH notes that while individual study findings are promising, evidence quality varies and more rigorous human trials are needed before definitive conclusions can be drawn

described in published trial data as contributing to energy-expenditure pathways