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doi: 10.1016/J.OPHTHA.2014.05.013/ATTACHMENT/4DFFCC6A-BE96-4720-96C7-1DA6395D6ECE/MMC5.PDF 75 CuiQNSteinLMFortinSMHayesMR

Nausea severity peaks during the titration phase (weeks 18) because amylin receptor density in the area postrema is high and initial agonism triggers emetic signalling before downregulation occurs

Additionally, human-based multi-omics trials are essential to confirm molecular targets and mechanistic pathways identified in preclinical research, paving the way for precision medicine applications

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RETA induced a significant yet transient decrease in food intake and substantial weight loss across three cohorts of DIO mice with consistent improvements in glucose tolerance and insulin resistance compared to Veh controls