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Although the optimal dose of LC supplementation for myocardial infarction is 3 g/day in terms of all-cause mortality [90], even lower LC intake elevates fasting plasma TMAO [16,17,18, 58, 59], which is ten-fold higher than control after 3 months of supplementation [16, 17]

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As BCAA concentration increases, its degradation rate proportionally rises (17)

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Read the evidence A 2017 meta-analysis (N = 1,211) found that in patients with hyperuricaemia and CKD, urate-lowering treatment slowed renal function decline, limited proteinuria and reduced the relative risk of cardiovascular events or renal failure by over 50% 12 A 2020 meta-analysis (N = 6,458) found that urate-lowering treatment did not significantly reduce the risk of major adverse cardiovascular events, kidney failure or all-cause mortality

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