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A large quantity of clinical evidence has shown that DBS can effectively alleviate tremors, bradykinesia, and muscle rigidity, thus improving patients quality of life

The unmet need of improving/achieving the glycated hemoglobin (HbA1c) goal is strongly associated with the requirement for diverse therapeutic options, namely, for the individualization of care (personalized medicine)

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Moreover, Glp1r Tie2/ mice do not display differences in renal artery or kidney Glp1r expression, as opposed to Glp1r VSM/ mice in which Glp1r expression is markedly reduced in these structures, further highlighting that VSMCs are the main renal GLP-1Rexpressing cell type