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basal insulin cut from 47 to 8-20 IU replacing basal-bolus (SURPASS-6)

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They are used to correct or prevent B12 deficiency and support energy, metabolism, mood, and cognitive function

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Table 1: Vitamin B12 treatment methods compared in this study The effectiveness of both vitamin B12 supplementation methods In both groups, vitamin B12 deficiencies were treated for all patients over the course of 6 months, showing no significant difference in concentration between oral or intramuscular supplementation

A multicenter trial of 390 patients with diabetes mellitus receiving insulin therapy who were randomized to receive metformin, 850 mg three times daily, or placebo assessed the risk of vitamin B 12 deficiency and low vitamin B 12 levels over four years