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Glutathione depleting agents and lipid peroxidation

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These are vagus-independent actions and are exerted via binding to specific amylin receptors in the hindbrain area postrema (198), which is in contrast with the peripheral neural mechanisms engaged by most other gut peptides involved in energy homeostasis system regulation

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Both preclinical and clinical studies show that progression from steatotic liver to MASH correlates with increased intrahepatic frequencies of IL-17 + CD4 + T cells (118)

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