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This structural and pharmacological relationship between MT-II and PT-141 makes them directly comparable research tools for dissecting the contributions of MC1R activation to MT-IIs biological profile , with PT-141 functioning as an MT-II analogue from which the tanning biology has been partially removed while preserving central melanocortin receptor activity

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The animals fed a selenium-deficient diet recapitulated some of the pathological manifestations of KBD, strongly supporting the notion that selenium deficiency is critically associated with the development of this endemic arthropathy

More research teams are required to produce similar results to see breakthroughs to the clinical implementation approach

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