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They can promote mitochondrial biogenesis (increasing the number and function of mitochondria within cells), increase antioxidant activity, stabilize mitochondrial membranes, assist with ATP production, and modulate cell signaling and protection

Maintaining improvements long-term requires either continued use or transition to lifestyle interventions that sustain AMPK activation (resistance training, caloric cycling)

They are especially beneficial for those who may have a vitamin B12 deficiency

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Because the body is efficient at excreting excess B12 through urine, there is no established tolerable upper intake level (UL) for the vitamin