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The multifunctional docking site of MET recruits to the plasma membrane stereotypical adaptor/signaling molecules such as Gab1, Grb2, SPH2, phosphoinositide-3-kinase (PI-3K), Src, phospholipase c gamma (PLC), Shc, and signal transducer and activator of transcription 3 (STAT3) (Ponzetto et al., 1994

JAMA 325, 765779

Charrire, G

The primary safety concern is gastrointestinal burden: both medications can cause nausea, constipation, and abdominal discomfort, and their effects may compound

Suitable for men and women above the age of 18 years

While the overall risk remains relatively low, the association has raised alarms among healthcare professionals and regulatory agencies