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The tri-agonist treatment prevented excessive weight gain in vehicle-treated mice to a greater degree than the GLP-1/GIP coagonist, and this observation was not due to any alterations in cumulative food intake

Most people who stop using GLP-1s regain the weight they lost, even with sustained lifestyle changes

Please discuss any concerns with your clinician before beginning treatment, and review all provided safety information

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Verfaillie et al., 2012)

3 Metabolic outcomes of GLP-1RAs in PCOS: from evidence synthesis to Bayesian probability integration The interpretation of clinical evidence presented below follows the core tension between metabolic risk fertility window, as illustrated in Figure 1A: achieving metabolic optimization within a finite reproductive window while strictly adhering to discontinuation and washout protocols to mitigate periconception exposure risks