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This particular interaction has been described in molecular details by both NMR spectroscopy and X-ray crystallography using recombinant isolated ECDs 4,5,6,7,8

The viral genome The SARS-CoV-2 genome is a 29.9-kb RNA that consists of 14 open reading frames (ORFs) encoding two large polyproteins (ORF1a and ORF1b) and 13 small ORFs that encode viral structural proteins and other polypeptides

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and Johnson, T.L., "Using yeast genetics to study RNA splicing", Methods Mol Biol 1126: 285-298 (2014)

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