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It means that the biological environment in which those drugs operate may matter more than previously understood

Transplantation of embryonic dopamine neurons for severe Parkinsons disease

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For performance-focused patients, VO2 max testing at baseline and after 12 weeks provides an objective measure of cardiorespiratory adaptation

10 or 15 mg once weekly) vs Reduce to tirzepatide 5 mg once weekly vs Placebo for 52 weeks (randomized 3:3:2 at week 60) Primary outcome: Percent change in bodyweight from baseline to week 112 Results: Primary outcome (percent change in bodyweight at week 112): Tirzepatide MTD -21.9%, Tirzepatide 5 mg -16.6%, Placebo -9.9% (estimated treatment difference vs placebo -12.0% for MTD and -6.6% for 5 mg