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An additional and important caution applies if either agent is used alongside insulin or a sulfonylurea: retatrutide's glucose-lowering activity may increase the risk of hypoglycaemia in this context, and dose review of any existing antidiabetic medicines would be essential before combining treatments

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The convenience of oral tablets may matter to patients who sometimes avoid injectables out of aversion to needles

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Blood sugar, cholesterol, and insulin sensitivity improve

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