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It is derived from several observations, including the inability of antibodies to minor populations of surface proteins for example, antibodies to NA on influenza viruses or to an altered conformation of the rabies G protein to neutralize the corresponding viruses owing to insufficient coating of virions

These concerns are being addressed in a current phase 3, double-blind, randomized, placebo-controlled, multicenter study of Voxelotor (ClinicalTrials.gov Identifier: NCT03036813) (Vichinsky et al., 2019)

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Their Medicare coverage outcome is entirely different, and the difference has nothing to do with the chemistry