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phase 2 weight-loss data published in 2023 reported mean reductions of roughly 24% at the highest dose over 48 weeks, and phase 3 trials are underway

PMID: 29413686

These benefits may extend to individuals with MASH, however there are currently no retatrutide trials planned in populations with MASLD/MASH

Before you begin this medication, it can be useful to review the following with a healthcare provider: CagriSema is an investigational treatment that should be used only under a clinicians supervision, as complete data on its long-term safety are not yet available

2025;26(388):e080679