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The American Society of Anesthesiologists (ASA) put out a warning in June asking patients to stop taking GLP-1 drugs at least a week before elective surgeries due to an increased risk of the drugs causing vomiting during operation
The dual GIP/GLP-1 mechanism of tirzepatide may produce a different GI side-effect profile in some patients
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However, they found that in knock-in mice expressing MOR mutant S375A substitution, proposed by these authors to be the primary site of morphine-induced phosphorylation of MOR responsible for desensitization (Schulz et al., 2004), morphine tolerance was not affected (Grecksch et al., 2011)
These work quickly to neutralize stomach acid and provide immediate relief, but their effects are short-lived
Notably, SCFAs, tryptophan metabolites, and other bacterial byproducts can reach the CNS via the portal and systemic circulation, modulating neuroinflammation, neurotransmitter biosynthesis, and even behavior
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