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Its pro-angiogenic activity also carries a theoretical concern: any compound promoting new blood vessel formation could support tumor vascularization in individuals with undetected malignancies

Patients should receive comprehensive education regarding signs and symptoms that could indicate malignancy and should be counseled to report any new symptoms or changes promptly

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Institutional Review Board Statement This research was approved by the local Ethic Committee (case number 380-59-10106-17-100/290) and by the Directorate of Veterinary (UP/I-322-01/15-01/22)