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[2] Chromium : Studies show only a very small effect on weight loss, with results controversial and often dependent on diet, dosage, and baseline chromium status

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Moreover, 2.5 mg/kg intragastrically application of cross-linked bromelain with organic acids and polysaccharides (CL-bromelain) for 7 days considerably showed anti-inflammatory effects via reduction of NF-B activity and COX-2 mRNA expression in rat livers (145)

A key consideration is blood thickening, which can have implications for cardiovascular health

Reduced appetite means every calorie consumed needs to count more