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In vitro , the phenomenon that berberine enhanced the GLP-1/GLP-1R/PKA signal pathway had also been observed, which confirmed the results of animal experiments

The current study also identified increased putrescine biosynthesis, a polyamine, that when present at non-optimal concentrations could be cytostatic/cytotoxic

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

However, no further improvement was observed (Fig

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